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Chen

陳清漂  教授

 

 

 

 

 

 

  聯絡方式

 

  辦公室

 

  實驗室

 

  Email

chinpiao@gms.ndhu.edu.tw

 

  實驗室個別網頁網址

 http://faculty.ndhu.edu.tw/~chinpiao/index.htm

  主要學歷

 國立臺灣師範大學化學系學士(1975-1979)

美國匹茲堡大學化學系博士(1988-1992)【指導教授Prof. Kozikowski, A. P.
 

  現職經歷


基隆信義國中理化教師(1979-1988)

美國哈佛大學化學系博士後研究員(1993-1995)【指導教授Prof. Kishi, Y.

工研院材料所研究員(1995)

慈濟大學醫技系副教授(1995-2001)

國立東華大學化學系助教授(2001-2003 )

國立東華大學化學系副教授(2003/8- )

國立東華大學化學系教授(2010/8- )

  研究方向

 

1. 不對稱合成反應

2. 藥物與天然物合成

3. 反應的開發與探討
 

  學術著作

 

1 Xu, Y.-Z.; Chen, C. 2007, “Syntheses of deuterium labeled 2,5-dimethoxyamphetamine

(DMA), 4-bromo-2,5-dimethoxyamphetamine (DOB), and 4-methoxyamphetamine (PMA) as internal standards for quantitative analyses by GC-MS”J. Chin. Chem. Soc. 54, 2, 493-502.(2007. 4.) SCI

2 Liu, S.-Y.; Lo, C.-T.; Chen, C.; Liu, M.-Y.; Chen, J.-H.; Peng K.-C.* 2007, “Efficient

Isolation of Anthraquinone-Derivatives from Trichoderma harzianum ETS 323”J. Biochem. Bioph. Meth. 70, 391-395. (2007. 4. 10) SCI

3 Shaikh, A. C.; Wang, Y.-Y.; Chen, C. 2007, “Synthesis of deuterium labelled standards of (±)-DOM and (±)-MMDA”J. Labelled. Comp. Radiopharm. 50, 7, 660-665. (2007. 6.) SCI

4 Chen, Y.-J.; Chen, C. 2007, “Enantioselective ring-opening reaction of meso-epoxide with ArSH catalyzed by a C2-symmetric chiral bipyridyldiol-titanium complex”Tetrahedron: Asymmetry 18, 11, 1313-1319. (2007. 6.) SCI

5 Leong, M.; Chen, C.; Shar, K. C.; Shiuan, D.* 2007, “Selection and characterization of lipase abzyme from phage displayed antibody libraries”Biochem. Biophys. Res. Commun. 361, 567–573. (2007.9) SCI

6 Chen, Y.-J.; Chen, C. 2007, “Synthesis of deuterium labelled standards of dihydroetorphine and etorphine” J. Labelled. Comp. Radiopharm. 50, 1143-1147. (2007.11) SCI

7 Wang, Y.-Y.; Chen, C. 2007, “Synthesis of deuterium labelled tryptamine derivatives”J. Chin. Chem. Soc. 54, 5, 1363-1368. (2007.10) SCI

8 Wang, Y.-Y.; Chen, C. 2007, “Synthesis of deuterium labelled standards of bufotenine

(5-HO-DMT)”J. Labelled. Comp. Radiopharm. 50, 14, 1262-1265. (2007.12) SCI

9 Chang, T.-C.; Chen, C. 2008, “Chiral Aryl Pyridyl Alcohols as Enantioselective Catalysts in the Addition of Diethylzinc to Substituted Benzaldehydes”J. Chin. Chem. Soc. 55, 3, 606-615. (2008.6.1) SCI

10 Shaikh, A. C.; Chen, C. 2008, “Synthesis of deuterium labeled zaleplon-d5 as an internal standard”, J. Labelled. Comp. Radiopharm.51, 72-76. (2008.1.14)

11 Hsua,T.-S.; Chen, C.; Lee, P.-T.; Chiu, S.-J.; Liua, H.-F.; Chao, J.-I. 2008,

“7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound

induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway”Cancer Chemoth. Pharm. DOI 10.1007/s00280-007-0667-5. (2008.) SCI

12 You, Z.-Y.; Chen, Y.-J.; Wang, Y.-Y.; Chen, C. 2008, “Synthesis of Deuterium Labelled Standards of 1-Benzylpiperazine, Fenetylline, Nicocodeine and Nicomorphine”J. Chin. Chem. Soc. 55, 3, 663-667. (2008.6.1) SCI

13 Chen, Y.-J.; Chen, C. 2008, Catalytic enantioselective Strecker-type reaction of phosphinoyl ketimines by bipyridyldiol derived chiral zirconium catalysts. Tetrahedron: Asymmetry, 19, 18, 2201-2209. (2008.9.22) SCI

14 Xu, Y.-Z.; Lin, H.-R. Lua, A.-C.; Chen, C. 2008, Determination of dimethoxyphenethylamine derivatives in urine by deuterium labeled internal standards. J. Serb. Chem. Soc. 73, 12, 1223-1233. (2008.12) SCI

15 Srimurugan, S.; Murugan, K.; Chen, C. 2009, A Facile Method for the Preparation of

[2H3]-Sufentanil and Its Metabolites. Chem. Pharm. Bull. 57, 12, 1421-1424. (2009.12) SCI

16 Zheng, W.-W.; Hsieh, Y.-H.; Chiu, Y.-C.; Cai, S.-J.; Cheng, C.-L.; Chen, C. 2009, Organic functionalisation of ultradispersed nanodiamond: Synthesis and applications. J. Mater. Chem. 19, 8432-8441. SCI

17 Huang, X.-R.; Chen, C.; Lee, G.-H.; Peng, S.-M. 2009, A Spirocyclic Chiral Borate for

Catalytic Enantioselective Nozaki-Hiyama Allylation of Ketones. Adv. Syn. Catal. 351,

3089-3095. SCI

18 Murugan, K.; Srimurugan, S.; Chen, C. 2010, A mild, catalytic and efficient Nazarov

cyclization mediated by phosphomolybdic acid. Chem. Commun. 46, 1127-1129. SCI

19 Shaikh, A. C.; Chen, C. 2010, Facile and Efficient Aromatization of 1,4-Dihydropyridines with M(NO3)2·XH2O, TNCB, TBAP and HMTAI and Preparation of Deuterium Labeled Dehydronifedipine from Nifedipine-d3. Bioorg. Med. Chem. Lett. 20, 3664-3668. SCI

20 Liu, K.-K.; Zheng,W.-W.;Wang, C.-C.; Chiu, Y.-C.; Cheng*, C.-L.; Lo,Y.-S.; Chen*, C.; Chao*, J.-I. 2010, Covalent linkage of nanodiamond-paclitaxel for drug delivery and cancer therapy. Nanotechnology 21, 315106. SCI

21 Lin, Z.-C.; Chen*, C. 2010, Asymmetric synthesis of a new salen type-titanium complex as the catalyst for asymmetric trimethylsilylcyanation of aldehydes. J. Chin. Chem. Soc. 57, 726-737. SCI

22 Huang, X.-R.; Chen*, C. 2010, A chiral spirocyclic borate ligand as catalyst for the

enantioselective Nozaki-Hiyama-Kishi allylation of arylaldehydes. Tetrahedron: Asymmetry 21, 2999-3004. SCI

23 Huang, X.-R.; Lee, G. H.; Chen*, C. 2011, A Facile Synthesis synthesis and structural

verification of etorphine and dihydroetorphine. J. Chin. Chem. Soc. 58, 101-107. SCI

24 Tsai, C.-C.; Liu, H.-F.; Hsu, K.-C.; Yang, J.-M.; Chen, C.; Liu, K.-K.; Hsu, T.-S.; Jui-I Chao*, J. -I. 2011, 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione(PT-262), a novel ROCK inhibitor blocks cytoskeleton function and cell migration. Biochem. Pharmacol. 81, 856-865. SCI

25 Tsai, M. J.; Chen, C.; Chen, S.-H.; Yen Ta Huang, Y. T.; Ted H. Chiu*, T. H. 2011,

Pomalidomide Suppresses Cerulein-induced Acute Pancreatitis in Mice. J. Gastroenterol. 46, 822-833.. SCI

26 Huang, X.-R.; Pan, X.-H.; Chen*, C. 2011, C2-Symmetric Bipyridyldiols as the Promising Enantioselective Catalysts in Nozaki-Hiyama Allylation. Adv. Syn. Catal. 353, 1949-1954. SCI

27 Ajam C. Shaikh, A. C.; Chen*, C. 2011, An Easy and Efficient Synthesis of

Bisindolylmethanes and Tetraindolylmethane Troger’s Base Catatlyzed by AgBF4. J. Chin. 3 Chem. Soc. 58, 899-905. SCI

28 Murugan, K.; Srimurugan, S.; Chen*, C. 2011, Silicomolybdic acid supported on silica-gel: An efficient catalyst for Hosomi-Sakurai allylation reactions. Tetrahedron 67, 5621-5629. SCI

29 Sulake, R. S.; Chen*, C.; Lin, H.-R.; Lua, A.-C. 2011, Synthesis of deuterium labeled

ketamine metabolite dehydronorketamine-d4. Bioorg. Med. Chem. Lett. 21, 5719–5721. SCI

30 Murugan, K.; Chen*, C. 2011, HClO4-supported on silica gel: a mild and efficient catalyst for Hosomi-Sakurai reaction. Tetrahedron Lett. 52, 5827–5830. SCI

31 Tripathi, S.; Shaikh, A. C.; Chen*, C. 2011, Facile carbohydrate-based stereocontrolled

synthesis of (+)-pericosines A and B. Org. Biomol. Chem. 9, 7306-7308. SCI

32 Tripathi, S.; Chan*, M.-H.; Chen*, C. 2012, An expedient synthesis of honokiol and its

analogues as potential neuropreventive agents. Bioorg. Med. Chem. Lett. 22, 216–221.

33 Srimurugan, S.; Su, C.-J.; Shu, H.-C.; Murugan K.; Chen*, C. 2012, A facile and improved synthesis of desomorphine and its deuterium labeled analogue. Monatsh. Chem. 143, 171–174. SCI

34 Ramalingam, B.; Chen*, C.; Lee, G.-H. 2012, Camphor-Based Schiff Base Ligand SBAIB: An Enantioselective Catalyst for Addition of Phenylacetylene to Aldehydes. Org. Biomol. Chem. 10, 1625-1638. SCI

35 Maity, A. N.; Shaikh, A. C.; Srimurugan, S.; Wu, C.-J.; Chen, C.; Ke, S.-C.* 2012, Synthesis of 4-thia-[6-13C]lysine from [2-13C]glycine: access to site-directed isotopomers of 2-aminoethanol, 2-bromoethylamine and 4-thialysine. Amino Acids 42, 309-315. SCI

36 Wu, P.-S.; Chen*, C. 2012, Synthesis of chiral pyridylphenols for the enantioselective

addition of diethylzinc to aldehydes. J. Chin. Chem. Soc. 59, 768-781. SCI

37 Dhondge, A. P.; Shaikh, A. C.; Chen*, C. 2012, A pineno-salen type catalyst for the

enantioselective Nozaki-Hiyama-Kishi reaction. Tetrahedron: Asymmetry 23, 723–733. SCI