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Kuo-Ting Chen

Kuo-Ting CHEN

Assistant Professor

  Organic Chemistry






Lab    :(03)-890-3576


D318 Science building


D309、310 Science building



    Personal Website



Ph.D., Pharmacy, National Taiwan University, Taiwan, 2009–2015.
Research assistant, Academia Sinica, Taiwan, 2008-2009.
M.S., Institute of Nuclear Energy Research, Taiwan, 2007.
M.S., Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan, 2006–2007.
B.S., Atomic Science, National Tsing Hua University, Taiwan, 2002–2005.


Scientific Researcher (permanent position), Erasmus MC, The Netherlands, 2019-present.
Scientific Researcher, Erasmus MC, The Netherlands, 2017-2019.
Postdoctoral Fellow, TRIUMF, Canada, 2016-2017.
Postdoctoral Fellow, Academia Sinica, Taiwan, 2015–2016.

    Research Interests


Organic chemistry, soft materials, luminescent materials, photochemistry,

fluorous chemistry


   Selected Publications

 1. Chen KT, Nieuwenhuizen J, Handula M, Seimbille Y, “Development of a Novel Dual-Modality Fluorescence/Nuclear Imaging

agent for Dual-labeling of Biovectors via a CBT/1,2-aminothiol click reaction”, 2019, manuscript.

2. Chen KT, Nguyen K, Ieritano C, Gao F, Seimbille Y, “A Flexible Synthesis of 68Ga-Labeled Carbonic Anhydrase IX (CAIX)-

Targeted Molecules via CBT/1,2-Aminothiol Click Reaction.Molecules 2019, 24(1), 23. IF: 3.098. Rank: 68/170.

3. Gao F, Ieritano C, Chen KT, Dias GM, Rousseau J, Bénard F, Seimbille Y, “Two bifunctional desferrioxamine chelators for

bioorthogonal labeling of biovectors with zirconium-89.Org Biomol Chem. 2018, 16, 5102-5106. IF: 3.564. Rank: 16/57.

Citation: 4.

4. Chen KT, Ieritano C, Seimbille Y, “Early-Stage Incorporation Strategy for Regioselective Labeling of Peptides using the 2-

Cyanobenzothiazole/1,2-Aminothiol Bioorthogonal Click Reaction.ChemistryOpen, 2018, 7, 256-26. IF: 2.801. Rank: 72/170.

Citation: 2.

5. Chen KT, Lin CK, Guo CW, Chang YF, Hu CM, Lin HH, Lai YT, Cheng TJR, Cheng WC, “Effect of the lipid II sugar moiety

on bacterial transglycosylase: the 4-hydroxy epimer of lipid II is a TGase inhibitorChemical Communications, 2017, 53, 771-

774. IF: 6.290. Rank: 28/170. Citation: 1.

6. Wang HW, Chen KT, Cheng WC, Liang PH, “Development of a liposome-based assay for Lipid II and analog translocation by

flippase MurJ” Abstracts of papers of the American Chemical Society, 2016, conference paper.

7. Chen KT, Chen PT, Lin CK, Huang LY, Hu CM, Chang YF, Hsu HT, Cheng TJR, Wu YT and Cheng WC, “Structural

Investigation of Park’s Nucleotide on Bacterial Translocase MraY: Discovery of Unexpected MraY Inhibitors” Scientific

Reports, 2016, 6, 31579. IF: 4.122. Rank: 12/64. Citation: 3.

8. Chen KT, Huang DY, Chiu CH, Lin WW, Liang PH, Cheng WC, “Synthesis of Diverse N-Substituted Muramyl Dipeptide

Derivatives and Their Use in a Study of Human NOD2 Stimulation Activity”, Chemistry-a European Journal, 2015, 21, 11984-

11988. IF: 5.160. Rank: 37/170. Citation: 7.

9. Lin CK, Chen KT, Hu CM, Yun WY, Cheng WC, “Synthesis of 1-C-Glycoside-Linked Lipid II Analogues Toward Bacterial

Transglycosylase Inhibition.”, Chemistry-a European Journal, 2015, 21, 7511-7519. IF: 5.160. Rank: 37/170. Citation: 7.

10. Chen KT, Kuan YC, Fu WC, Liang PH, Cheng TJ, Wong CH, Cheng WC, “Rapid preparation of mycobacterium N-glycolyl

Lipid I and Lipid II derivatives: a biocatalytic approach.”, Chemistry-a European Journal, 2013, 19, 834-838. IF: 5.160. Rank:

37/170. Citation: 14.

11. Shih HW, Chen KT, Cheng WC, “One-pot synthesis of phosphate diesters and phosphonate monoesters via a combination of

microwave-CCl3CN–pyridine coupling conditions.” Tetrahedron Letters, 2012, 53, 243-246. IF: 2.379. 27/57. Citation: 6.

12. Shih HW, Chen KT, Cheng TJ, Wong CH, Cheng WC, “A New Synthetic Approach toward Bacterial Transglycosylase

Substrates, Lipid II and Lipid IV.”, Organic Letters, 2011, 13, 4600-4603. IF: 6.492. Rank: 3/57. Citation: 27.

13. Meng FC, Chen KT, Huang LY, Shih HW, Chang HH, Nien FY, Liang PH, Cheng TJ, Wong CH, Cheng WC, “Total Synthesis

of Polyprenyl N-Glycolyl Lipid II as a Mycobacterial Transglycosylase Substrate.”, Organic Letters, 2011, 13, 5306-5309. IF:

6.492. Rank: 3/57. Citation: 17.

14. Cheng TJ, Wu YT, Yang ST, Lo KH, Chen SK, Chen YH, Huang WI, Yuan CH, Guo CW, Huang LY, Chen KT, Shih HW,

Cheng YS, Cheng WC, Wong CH, “High-throughput identification of antibacterials against methicillin-resistant

Staphylococcus aureus (MRSA) and the transglycosylase.”, Bioorganic & medicinal chemistry, 2010, 18, 8512-8529. IF: 2.881.

Rank: 150/293. Citation: 45.

15. Shih HW, Chen KT, Chen SK, Huang CY, Cheng TJ, Ma C, Wong CH, Cheng WC, “Combinatorial approach toward synthesis

of small molecule libraries as bacterial transglycosylase inhibitors.”, Organic & biomolecular chemistry, 2010, 8, 2586-2593.

IF: 3.564. Rank: 16/57. Citation: 26

16. Chen KT, Lee TW, Lo JM, “In vivo examination of 188Re(I)-tricarbonyl-labeled trastuzumab to target HER2-overexpressing

breast cancer”, Nuclear Medicine and Biology, 2009, 36, 355–361. IF: 2.203. Rank: 61/129. Citation: 22.

17. Chen WJ, Yen CL, Lo ST, Chen KT, Lo JM, “Direct 99mTc labeling of Herceptin (trastuzumab) by 99mTc(I) tricarbonyl ion”, Applied Radiation and Isotopes, 2008, 66, 340-345. IF: 1.123. Rank: 105/129. Citation: 18.