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chyan

錢嘉琳  教授

 

 

  聯絡方式

研究室:(03)-890-3589

實驗室:(03)-890-3590

  辦公室

理工三館B316

  實驗室

理工三館A209/A213

  Email

chyan@gms.ndhu.edu.tw

 

  實驗室個別網頁網址

 

  主要學歷

 1980-1984: 國立清華大學化學系學士

1988-1994: Rutgers University化學博士
 

  現職經歷


1988-1991: Rutgers University TA

1991-1994: Rutgers University RA

1994-1999: 中央研究院生醫所博士後研究

1999-2005.08: 國立東華大學化學系助教授

2005.08-2017.08: 國立東華大學化學系副教授

2017.08-至今國立東華大學化學系教授
 

  研究方向

 

1. 生物化學

2.生物核磁共振光譜

3.生物物理化學

4.結構生物學

 

  學術著作

 

1. Y.-L. Yeh, C.-H. Chang, C.-L. Chyan, and S.-H. Lin, “Atomic Force Microscopic and Theoretical Study of Protein Folding and Unfolding”, Instruments Today 25 (5), 39-45 (2004)

2. C.-M. Chen, C.-L. Chyan, T.-T. Lee, S.-H. Huang, and J. T.C. Tzen, “Caleosin Stabilizes Artificial Oil Bodies as Nanoparticles”, J. of Agri. And Food Chem. 52 (12), 3982-7 (2004) (SCI).

3. T.-H. Lin, J.-W.Huang, H..-b.. Huang, Y..-c.. Chen, C.-Y. Liu, C.-j. Lo, T. C. Tang, and C.-L. Chyan, “1H, 15N, and 13C Resonance Assignments of Calmodulin Complexed with the Calmodulin-Binding Domain of Protein Phosphatase 2B”, J. of Biomol. NMR, 29, 531-2 (2004) (SCI).

4. J.-H. Shyu, C.-L. Chyan, J. T. C. Tzen, and W.-M. Chou, “Molecular Cloning, Expression, and Functional Characterization of a Cystatin from Pineapple Stem”, Bioscience, Biotechnology, and Biochemistry 68 (8), 1681-9 (2004) (SCI).

5. C.-L. Chyan, F.-C. Lin, H. Peng, J.-M. Yuan, C.-H. Chang, S.-H. Lin, and G. Yang, “Reversible Mechanical Unfolding of Single Ubiquitin Molecules”, Biophysical J. 87, 3995-4006(2004) (SCI).

6. Y.-L. Yeh, C.-H. Chang, K.-K. Liang, Y.-J. Shiu, C. Su, M. Hayashi, C.-L. Chyan, G. Yang, Y. Moe, Y.-J. Yan, S.-H. Lin, “Atomic force microscopic and theoretical studies of poly-ubiquitin proteins”, Chemical Physics Letters 399, 440–445 (2004) (SCI).

7. C.-L. Chyan, P.-C. Huang, T.-H. Lin, J.-W. Huang, S.-S. Lin, H.-b. Huang and Y.-C. Chen, “Purification, crystallization and preliminary crystallographic studies of the Camodulin-OLFp complex” Acta Crystallographica F61, 785-787 (2005) (SCI).

8. C.-L. Chyan, T.T.-T. Lee, C.-P. Liu, Y.-C. Yang, J.T.-C. Tzen, and W.-M. Chou, “Cloning and Expression of a Seed-Specific Metallothionein-Like Protein from Sesame”Bioscience, Biotechnology, and Biochemistry 69 (12), 344-351 (2005) (SCI).

9. Y.R. Chen, H.B. Huang, C.-L. Chyan, M.S. Shiao, T.H. Lin and Y.C. Chen, “The Effect of A Conformation on the Metal Affinity and Aggregation Mechanism Studied by Circular  Dichroism Spectroscopy”, J. Biochem. 139, 733–740 (2006) (SCI).

10. M.Q. Liao, Y.J. Tzeng, Lea Y.X. Chang, H.B. Huang, T.H. Lin, C.L. Chyan, Y.C.Chen,* “The Correlation between Neurotoxicity, Aggregative Ability and Secondary 2 Structure Studied by Sequence Truncated A peptides” FEBS Lett 581, 1161-1165. (2007) (SCI IF 3.264)

12. Y. M.Yuan, C.-L.Chyan, H. X. Zhou, T. Y. Chung, H. Peng, G. Ping, G. Yang*,

"The effects of macromolecular crowding on the mechanical stability of protein molecules" Protein Sci. 17(12), 2156-66 (2008) (SCI IF 3.115).

13. Liu, T. H., Chyan, C. L., Li, F. Y., and Tzen, J. T. (2009) Stability of artificial oil bodies constituted with recombinant caleosins, J Agric Food Chem 57, 2308-2313 (2009 March).

14. Huang, Y. C., Chen, Y. C., Tsay, H. J., Chyan, C. L., Chen, C. Y., Huang, H. B., and Lin, T. H. (2010) The effect of PKA-phosphorylation on the structure of inhibitor-1 studied by NMR spectroscopy, J Biochem 147, 273-278 (2010 Feb).

15. Lu, H. C., Jiang, P. L., Hsu, L. R., Chyan, C. L., and Tzen, J. T. (2010)

Characterization of oil bodies in adlay (Coix lachryma-jobi L), Biosci Biotechnol Biochem 74, 1841-1847 (2010 Sep).

16. Liu, T. H., Chyan, C. L., Li, F. Y., Chen, Y. J., and Tzen, J. T. C. (2011) Engineering lysine-rich caleosins as carrier proteins to render biotin as a hapten on artificial oil bodies for antibody production, Biotechnol Progr 27, 1760-1767 (2011 Nov).

17. Irene, D., Chen, B. J., Lo, S. H., Liu, T. H., Tzen, J. T., and Chyan, C. L.(2012) Resonance assignments and secondary structure of a phytocystatin from Ananas comosus, Biomol NMR Assign 6, 99-101 (2012 April).

18. Zulueta, M. M., Lin, S. Y., Lin, Y. T., Huang, C. J., Wang, C. C., Ku, C. C., Shi, Z., Chyan, C. L., Irene, D., Lim, L. H., Tsai, T. I.,  Hu, Y. P., Arco, S. D., Wong, C. H., and Hung, S. C. (2012) alpha-Glycosylation by D-glucosamine-derived donors: synthesis of heparosan and heparin analogues that interact with mycobacterial heparin-binding hemagglutinin, J Am Chem Soc 134, 8988-8995 (2012 May).

19. Chen, D. H., Chyan, C. L., Jiang, P. L., Chen, C. S., and Tzen, J. T. (2012) The same oleosin isoforms are present in oil bodies of rice embryo and aleurone layer while caleosin exists only in those of the embryo, Plant Physiol Biochem 60C, 18-24 (2012 Aug epub).

20. Irene, D., Huang, J. W., Chung, T. Y., Li, F. Y., Tzen, J. T., Lin, T. H., and Chyan, C. L. (2012) Binding orientation and specificity of calmodulin to rat olfactory cyclic nucleotide-gated ion channel, J Biomol Struct Dyn. (2012 Aug epub)

21. Jheng, Y. J., Tsai, W. Y., Chen, K. H., Lin, K. W., Chyan, C. L., Yang, C. C., and Lin, K. C. (2012) Recombinant dioscorins of the yam storage protein expressed in Escherichia coli exhibit antioxidant and immunomodulatory activities, Protein Expr Purif 85, 77-85 (2012 Sep epub).