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Yen-Peng Ho

Professor,  Analytical Chemistry






Lab   :(03)-890-3592


D418 Science building


D414、D415 Science building



    Personal Website

1991-1996: Ph. D. PhysicalChemistry, Case Western Reserve Univ. Cleveland, OH, USA
1982-1986: Bachelor degree of National Chung-Hsing University, Taichung, Taiwan


National Dong-Hwa University, department of chemistry, Professor 2007-
National Dong-Hwa University, department of chemistry, Associate Professor 2003-2007
National Dong-Hwa University, department of chemistry, Assistant Professor 1999-2003
University of Maryland, Maryland, USA, Research Associate 1997-1999
Colorado School of Mines, Golden, CO,USA, Research Associate 1996-1997

     Research Interests

Mass spectrometry
Bioanalytical Chemistry

     Selected Publications


1. Chen, C.-T.; Reddy, M.; Ma, Y.-R.; Ho, Y.-P. * “Mass spectrometric identification of pathogens in foods using a zirconium hydroxide immobilization approach”International J. Mass Spectrom. 2012. (In press)

2. Ho, Y.-P.* and Reddy, M. “Advances in Analysis of Pathogens by Mass Spectrometry” Mass Spectrom. Rev. 2011,  30, 1203-1224.

3. Ho, Y.-P.; Kuo, C.-W.; Hsu, Y.-T.; Huang, Y.-S.; Yew, L.-P.; Huang, W.-F.; Lin,K.-C.; Hsu, J.-H.* ” β-Actin is a downstream effector of the PI3K/AKT signaling pathway in myeloma cells” Mol. Cellular Biochem. 2011, 348, 129-139.

4. Chen, C.-T. Wang, L.-Y.; Ho, Y.-P.* “Highly Specific Enrichment of Phosphopeptides with Polyethylenimine-Modified Magnetic Nanoparticles for Mass Spectrometric Analysis”Anal. Bioanal. Chem. 2011, 399, 2795-2806.

5.Yang, S.-H.; Reddy, M.; Ho, Y.-P.* “Concentration and In-situ Detection of Peptides Using Liquid MALDI Matrices”Anal. Chem. 2010, 82, 44-48.

6. Reddy, M.; Hsu, W.I.; Hu, J.-F.; Ho, Y.-P.* “Digestion Completeness of Microwave-Assisted and Conventional Trypsin-Catalyzed Reactions” J. Amer. Soc.Mass Spec. 2010, 21, 421-424.

7. Ho, Y.-P.*; Reddy, M. “Identification of Pathogens Using Mass Spectrometry” Clinical Chem. 2010, 56, 525-536.

8. Ho, Y.-P.*; Reddy, M. “Identification of Pathogens Using Mass Spectrometry” Clinical Chem. 2010, 56, 525-536.

9. Li, Y.-Z.; Ho, Y.-P.; Chen, S.-T.; Shiuan, D.* “Proteomic Analysis of the Interactions between Mycoplasma hyopneumoniae and Porcine Tracheal Ciliated Cells” 2010, 160, 2248-2255.

10. Ho, C.-H.; Chen, L.; Ho Y.-P.; Yang, C.-L.* “Oxidative Decomposition of Reactive Blue CI 19 with Sodium Hypochlorite” Environ. Eng. Sci. 2010, 27, 101-109.

11. Li, Y.-Z.; Ho, Y.-P.; Chen, S.-T.; Chiou, T.-W.; Li, Z.-S.; Shiuan, D. “Proteomic comparative analysis of pathogenic strain 232 and avirulent strain J of Mycoplasma hyopneumoniae” Biochemsitry-Moscow 2009, 74 , 215-220.

12. Ho, Y.-P.* and Reddy, M. “Mass spectrometry-based approaches for the detection of proteins of  taphylococcus species” Infectious Disorders-Drug Targets 2008, 8, 166-182.

13. Reddy, p. M.; Ho, Y.-P.*; Shanker K.; Rohini, R.; Ravinder, V.* “Physicochemical and biological characterization of novel macrocycles derived from o-phthalaldehyde” European Journal of Medicinal Chemistry 2009, 44, 2621-2625.2

14. Rohini, R.; Shanker, K.; Reddy, P. M.; Ho, Y.-P*.; Ravinder, V., Mono and is-6-arylbenzimidazo[1,2-c]quinazolines: A new class of antimicrobial agents. European Journal of Medicinal Chemistry 2009, 44, 3330–3339.

15. Shanker K.; Rohini, R.; Ravinder, V.*; Reddy, P. M.; Ho, Y.-P.* “Ru(II) complexes of N4 and N2O2 macrocyclic Schiff base ligands: Their antibacterial and antifungal studies” Spectrochimica Acta Part A 2009, 73, 205–211.

16. Ho, Y.-P.* ; Reddy, M.; Chen, C.-T. and Lo, A. A.-L. “Applications of mass spectrometry in microbial forensics” Forensic Science Review 2009, 21, 25-50.

17. Sun, M.-C.; Chen, C.-D.; Huang, Y.-S.; Wu, Z-S. and Ho, Y.-P.* “Matrix Assisted Laser Desorption/Ionization-MS-Based Relative Quantification of Peptides and Proteins using Iodoacetamide and N-ethyliodoacetamide as Labeling Reagents” J. Sep. Sci. 2008, 31, 538-547.

18. Chang, C.-C.;Chen, P.-H.; Chu, H.-L.; Lee, T.-C.; Chou, C.-C.; Chao, J.-I.; Su, C.-Y.; Chen, J.-S., J.-S.; Tsai, C.-M.; Ho, Y.-P.; Sun, K.-W.; Cheng, C.-W.; Chen, F.-R. “Laser induced popcornlike conformational transition of nanodiamond as a nanoknife” Appl. Phys Lett. 2008, 93, 033905.

19. Liu, K.-K.; Chen, M.-F.; Chen, P.-Y.; Lee, T.; Cheng, C.-L.; Chang, C.-C.; Ho, Y.-P.; Chao, J.-I. “Alpha-bungarotoxin binding to target cell in a developing visual system by carboxylated nanodiamond” Nanotechnology, 2008, 19, 205102.

20. Hu, A.; Lo, A. A.-L.; Chen, C.-T.; Lin, K.-C.; Ho, Y.-P.* “Identifying Bacterial Species using Electrophoresis–Mass Spectrometry and SEQUEST with an Empirical Scoring Function” Electrophoresis. 2007, 28, 1387-1392.

21. Yang, M.-W.; Chen, L.-T.; Yang, Y.-C.*; Ho, Y.-P.* “Determining the Relative Bond Dissociation Energies of the Sodium Salts of Amino Acids by Mass Spectrometry and the Kinetic Method” J. Mass Spectrom. 2007, 42, 542-544.

22. Ho, Y.-P.; Yang, M.-W.; Chen, L.-T.; Yang, Y.-C.* “Relative Calcium Binding Strengths of Amino Acids Determined Using the Kinetic Method” Rapid Commun. Mass Spectrom. 2007, 21, 1083-1089.

23. Chang, C.-C.; Chao, J.-I.; Ho, Y.-P. ; Sun, K.-W.; Cheng, C.-L. “Nano-manipulation on cancer cells by protein-nanodiamond complex” Biophys. J. 2007, 332A-332A Suppl. S

24. Hu, A.; Chen, C.-T.;Tsai, P.-J.; Ho, Y.-P.* “Using Capillary Electrophoresis–Selective Tandem Mass Spectrometry to Identify Pathogens in Clinical Samples” Anal. Chem. 2006, 78, 5124-5133.

25. Lo, A. A.-L.; Hu, A.; Ho, Y.-P.* “Identification of Microbial Mixtures by LC-Selective Proteotypic-peptide Analysis (SPA)” J. Mass Spectrom. 2006, 41, 1049-1060.

26. Hu, A.; Tsai, P.-J.; Ho, Y.-P.* “Identification of Microbial Mixtures by Capillary Electrophoresis/Selective Tandem Mass Spectrometry” Anal. Chem. 2005, 77, 1488-1495. 3

27. Lin, S.-S.; Wu, C.-H.; Sun, M.-C.; Sun, C.-M.; Ho, Y.-P.* Microwave-Assisted Enzyme-Catalyzed Reactions in Various Solvent Systems J. Am. Soc. Mass Spectrom. 2005, 16, 581-588.

28. Chang, C.-C.; Lin, P.-Y.; Yeh, X.-C.; Deng, K.-H.; Ho, Y.-P.; Kan L.-S. Protein folding stabilizing time measurement: A direct folding process and three-dimensional random walk simulation Biochem. Biophys. Research Commun.2005, 328, 845–850. 


1.  Use of Matrices Comprising Liquids and Light Absorbing Particles for Analysis of Microorganisms by Laser Desorption Mass Spectrometry USA5948610